Editorial: Non-Coding RNAs in Neurodevelopmental Disorders

Editorial: Non-Coding RNAs in Neurodevelopmental Disorders

Long non-coding RNAs in neurodevelopmental disorders

Recent studies have emphasized an important role for long non-coding RNAs (lncRNA) in epigenetic regulation, development, and disease. Despite growing interest in lncRNAs, the mechanisms by which lncRNAs control cellular processes are still elusive. Improved understanding of these mechanisms is critical, because the majority of the mammalian genome is transcribed, in most cases resulting in non...

Editorial: Small Non-coding RNAs in Streptococci

Bacterial small RNAs (sRNAs) are post-transcriptional regulators of gene expression and the mechanisms by which this can occur have begun to be understood (Gottesman and Storz, 2011). In pathogenic bacteria, the importance of sRNAs-mediated regulation depends on a fine-tuning of the expression of various virulence genes (Papenfort and Vogel, 2010). For instance, RNAIII, a regulatory RNA from th...

The Role of Long Non-Coding RNAs in Ovarian Cancer

Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-co...

Long non-coding RNAs and their significance in human diseases

Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...